Lamchouri, F. and Settaf, A. and Cherrah, Y. and Hassar, M. and Zemzami, M. and Atif, N. and Nadori, E.B. and Zaid, A. and Lyoussi, B. (2000) In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines. Fitoterapia, 71 (1). pp. 50-54.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The alkaloidic fraction of the methanol extract of Peganum harmala seeds was tested in vitro on three tumoral cell-lines: UCP-Med and Med-mek Carcinoma, and UCP-Med Sarcoma. Proliferation was significantly reduced at all tested concentrations (20-120 μg/ml) during the first 24 h of contact. A cell lysis effect occurred after 24 h and increased thereafter to complete cell death within 48-72 h, depending on tested concentration. Copyright (C) 2000 Elsevier Science B.V.

Item Type: Article
Uncontrolled Keywords: alkaloid; Peganum harmala extract; plant extract, animal cell; animal model; article; cell death; controlled study; cytolysis; cytotoxicity; dose response; in vitro study; nonhuman; rat; tumor cell line, Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Male; Neoplasms, Experimental; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Rosales; Seeds; Tumor Cells, Cultured
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: SCIENTIFIC PRODUCTION > Pharmacology, Toxicology and Pharmaceutics
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:49
URI: http://eprints.umi.ac.ma/id/eprint/4422

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