Jouad, H. and Maghrani, M. and El Hassani, R.A. and Eddouks, M. (2003) Hypoglycemic Activity of Aqueous Extract of Eucalyptus globulus in Normal and Streptozotocin-Induced Diabetic Rats. Journal of Herbs, Spices and Medicinal Plants, 10 (4). pp. 19-28.

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Abstract

Single and repeated oral administration of the aqueous extract of Eucalyptus globulus leaves at the doses of 150 and 300 mg/kg body weight exhibited a significant, dose-dependent hypoglycemic effect in streptozotocin diabetic rats. In rats with a normal functioning pancreas, however, no significant changes in blood glucose levels were observed after a single or repeated oral administration of Eucalyptus globulus leaf extract. In diabetic rats, the repeated oral administration of Eucalyptus globulus aqueous leaf extract significantly increased the basal plasma insulin concentrations (P < 0.05). The oral acute toxicity study in mice demonstrated that the LD 50 value for the Eucalyptus globulus leaf tissue was 4.5 g/kg. The results support the validity of empirical uses of EG in the treatment of diabetes mellitus. © 2003 by The Haworth Press, Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Eucalyptus globulus extract; glucose; insulin; metformin; plant extract; unclassified drug; water, diabetes; traditional medicine, animal model; article; controlled study; diabetes mellitus; dose response; drug activity; drug effect; Eucalyptus; Eucalyptus globulus; glucose blood level; hypoglycemia; hypoglycemic activity; insulin blood level; LD 50; male; medicinal plant; nonhuman; plant leaf; rat; streptozocin diabetes; toxicity testing; traditional medicine, Eucalyptus; Eucalyptus globulus
Subjects: Medicine
Divisions: SCIENTIFIC PRODUCTION > Medicine
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:49
URI: http://eprints.umi.ac.ma/id/eprint/4356

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