El Midaoui, A. and Haddad, Y. and Couture, R. (2016) Beneficial effects of argan oil on blood pressure, insulin resistance, and oxidative stress in rat. Nutrition, 32 (10). pp. 1132-1137.

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Objective The aim of the present study was to investigate whether a 5-wk treatment with argan oil, which is known for its antioxidant properties, can reduce arterial hypertension, hyperglycemia, insulin resistance, and enhanced basal superoxide anion production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in the aorta of glucose-fed rats. Methods Sprague-Dawley rats had free access to a drinking solution containing 10 D-glucose or tap water (control) for 5 wk. The effect of argan oil in glucose-fed rats was compared with that of corn oil given daily by gavage (5 mL/kg) over a 5-wk period. Oxidative stress was evaluated by measuring the superoxide anion production and the NADPH oxidase activity using the lucigenin method. Results The 5-wk treatment with glucose led to increases in systolic blood pressure, plasma glucose, and insulin levels as well as an increase in the insulin resistance index in association with a rise in superoxide anion production and NADPH oxidase activity (sensitive to diphenyleneiodonium) in the aorta. The simultaneous treatment with argan oil prevented or significantly reduced all of these effects, yet the same treatment with corn oil had a positive effect only on hyperinsulinemia and insulin resistance. Conclusions The findings from the present study demonstrated that argan oil treatment reduced elevation of blood pressure, hyperglycemia, and insulin resistance through its antioxidative properties in glucose-fed rats. Hence, argan oil, which is now available in the market as a consumable food, may be of potential therapeutic value in the treatment of arterial hypertension and insulin resistance. © 2016 Elsevier Inc.

Item Type: Article
Uncontrolled Keywords: Argan oil; corn oil; edible oil; glucose; reduced nicotinamide adenine dinucleotide phosphate oxidase; superoxide; unclassified drug; antioxidant; argan oil; glucose; vegetable oil, animal experiment; animal model; aorta; Article; controlled study; diet therapy; enzyme activity; glucose blood level; hyperglycemia; hypertension; insulin blood level; insulin resistance; male; nonhuman; oxidative stress; priority journal; prophylaxis; rat; systolic blood pressure; weight gain; animal; blood pressure; drug effects; hyperglycemia; hypertension; insulin resistance; Sprague Dawley rat, Animals; Antioxidants; Blood Pressure; Glucose; Hyperglycemia; Hypertension; Insulin Resistance; Male; Oxidative Stress; Plant Oils; Rats; Rats, Sprague-Dawley
Subjects: Medicine
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:49
URI: http://eprints.umi.ac.ma/id/eprint/4309

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