Eddouks, M. and Hebi, M. and Ajebli, M. and El Hidani, A. and Sulpice, T. and Burcelin, R. (2018) Study of antidiabetic effect of Capparis spinosa L. and Calamintha officinalis Moench in diabetic mice Étude de l'activité antidiabétique de Capparis spinosa L. et de Calamintha officinalis Moench chez la souris diabétique. Phytotherapie, 16 (4). pp. 211-219.

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The anti-diabetic activities of Capparis spinosa (Cs) and Calamintha officinalis Moench (Co) were investigated in a diabetes mellitus model of mouse (high fat diet HFD), showing a pre-diabetic state. Decoction of the plants permits to obtain aqueous extracts (CoAE and CsAE). The administration of the aqueous extracts (CoAE 100 mg/kg and CsAE 100 mg/kg) and the aqueous extracts treated with heat (CoAE 100 mg/kg and CsAE 100mg/kg) during 3 weeks showed an anti-diabetic activity, a loss of weight as well as a decrease in the free fatty acid plasmatic concentrations. The aqueous extracts were extracted using two different solvents, dichloromethane, and butanol, producing three fractions of each extract. The anti-diabetic and hypolipidemic activities observed by CoAE (100 mg/kg) treatment were noticed in mice treated with the free water fraction (CoER 100 mg/kg) with the same effectiveness, concluding the hydrophilic molecules are involved in these pharmacological activities. The anti-diabetic activity observed in the mice CsAE (100 mg/kg) was found in the mice treated with the butanol fraction (CsBUT, 100 mg/kg) not correlated with the hypolipidemic activity found in dichloromethane fraction (CsDC, 100 mg/kg). This finding suggests that these two activities are due to lipophilic molecules. Finally for the two plants, the activity on the weight is found in the whole of the fractions, which shows that this activity is due to molecules of different polarity. © Lavoisier SAS 2017.

Item Type: Article
Uncontrolled Keywords: antidiabetic agent; Calamintha officinalis extract; Capparis spinosa extract; fatty acid; plant extract; unclassified drug, animal experiment; animal model; antidiabetic activity; Article; body weight loss; Calamintha officinalis; Capparis spinosa; diabetes mellitus; drug isolation; drug synthesis; fatty acid blood level; hypolipemia; impaired glucose tolerance; Lamiaceae; lipid diet; mouse; nonhuman
Subjects: Medicine
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:49
URI: http://eprints.umi.ac.ma/id/eprint/4296

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