Haggoud, A. and Ait M'Hand, R. and Reysset, G. and El M'Daghri, N. and Benbachir, M. and Moumni, M. (2001) Prevalence and characteristics of nim genes encoding 5-nitroimidazole resistance among Bacteroides strains isolated in Morocco. Microbial Drug Resistance, 7 (2). pp. 177-181.

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We report here an evaluation of the dissemination of nim genes, encoding 5-nitroimidazoles resistance, among Bacteroides clinical strains isolated in Morocco. This study was done using a PCR method. Among 60 strains studied, nine contain a copy of a him gene. The sequence determination of these genes showed that they are homologous to three nim genes previously characterized in strains isolated in France: nimB (five genes), nimC (three genes), and nimA (one gene). Although the nimA and nimC genes were previously identified on plasmids pIP417 and pIP419, respectively, we found here that they have a chromosomal location. The MICs of three 5-nitroimidazole antibiotics (metronidazole, ornidazole, and tinidazole) of the him gene-containing strains were very low (0.5-2 μg/ml), indicating that the nim genes were not efficiently expressed in these clinical isolates.

Item Type: Article
Uncontrolled Keywords: 4 nitroimidazole; bacterial protein; metronidazole; ornidazole; protein nim; tinidazole; unclassified drug, antibiotic resistance; article; bacterial gene; Bacteroides; chromosomal localization; controlled study; gene expression; gene sequence; genetic code; Morocco; nonhuman; plasmid; polymerase chain reaction; prevalence; priority journal; sequence analysis; sequence homology; strain difference, Bacteria (microorganisms); Bacteroides
Subjects: Immunology and Microbiology
Divisions: SCIENTIFIC PRODUCTION > Immunology and Microbiology
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:48
URI: http://eprints.umi.ac.ma/id/eprint/3616

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