El Hamdani, H. and El Amane, M. and Ba Mohammed, B. and Yamni, K. (2019) Synthesis, structural, spectral, and anticancer activity by computational molecular docking studies of the complexes M(II)(Th) 2 (H 2 O) 4 M(II) = Cd(II), Ni(II), Mn(II) and Cu(II); Th: Theophyllinate. Journal of Molecular Structure, 1181. pp. 627-635.

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Abstract

The aqua theophyllinate complexes of general formula M(II)(Th) 2 (H 2 O) 4 M(II) = Cd(II), Ni(II), Mn(II) and Cu(II), Th: theophyllinate, were prepared and characterized by the X-Ray diffraction analysis using the Fox program, infrared, UV–visible and TGA/DTA. These complexes were crystallized in the monoclinic system (P 2 1 /C). Moreover, the asymmetric unit of complexes contains one-half metal ion, one theophillinate anion and two coordinated water molecules. The intermolecular hydrogen bonds: O–H⋯O, O–H⋯N interactions are together playing a vital role in the stabilization of the crystal packing of all theophyllinate complexes. Additionally, molecular modelings of prepared complexes were investigated to study the expected anticancer activities of the prepared complexes. The results of molecular docking show that the complexes have a good affinity towards the protein kinase CK2. © 2019 Elsevier B.V.

Item Type: Article
Uncontrolled Keywords: Cadmium compounds; Coordination reactions; Hydrogen bonds; Infrared radiation; Manganese compounds; Metal ions; Metals; Molecular modeling; Molecules; Nickel compounds; Synthesis (chemical); X ray powder diffraction, Anticancer activities; Cd(II),Ni(II),Mn(II),Cu(II); Hydrogen interaction; Intermolecular hydrogen bonds; Monoclinic systems; Protein kinase CK2; TGA/DTA; Theophyllinate, Copper compounds
Subjects: Chemistry
Divisions: SCIENTIFIC PRODUCTION > Chemistry
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:45
URI: http://eprints.umi.ac.ma/id/eprint/1806

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