Aarjane, M. and Slassi, S. and Tazi, B. and Maouloua, M. and Amine, A. (2019) Novel series of acridone-1,2,3-triazole derivatives: microwave-assisted synthesis, DFT study and antibacterial activities. Journal of Chemical Sciences, 131 (8).

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Abstract: A series of novel acridones bearing a 1,2,3-triazole unit have been synthesized and characterized. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) was performed using both a conventional method and a microwave-assisted synthetic method. The in vitro antibacterial potencies of all the synthesized compounds were determined against five clinically isolated strains: Escherichia coli, Klebsiella pneumonia, Pseudomonas putida, Serratia marcescens and Staphyloccocus aureus. Furthermore, DFT quantum chemical calculations were carried out to investigate geometry structures, frontier molecular orbital and gap energies, and molecular electrostatic potential maps (MEP). Lipophilicities of the studied compounds were also determined. Graphic abstract: Novel acridone-1,2,3-triazole derivatives were synthesized using both a conventional and a microwave-assisted synthetic method. The antibacterial potencies of the compounds are reported. DFT quantum chemical calculations were carried out to investigate geometry structures, frontier molecular orbital and gap energies, and molecular electro static potential maps (MEP). Lipophilicities were also determined. Figure not available: see fulltext.. © 2019, Indian Academy of Sciences.

Item Type: Article
Uncontrolled Keywords: Copper compounds; Escherichia coli; Microwaves; Molecular orbitals, 1, 2, 3-triazole; Acridones; antibacterial activitiy; Copper(i) catalyzed azide alkyne cycloaddition (CuAAC); DFT study; Microwave assisted synthesis; Molecular electrostatic potentials; Quantum chemical calculations, Orbital calculations
Subjects: Chemistry
Divisions: SCIENTIFIC PRODUCTION > Chemistry
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:45
URI: http://eprints.umi.ac.ma/id/eprint/1800

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