Sbai, M. and Ait Lyazidi, S. and Lerner, D.A. and Del Castillo, B. and Martín, M.A. (1996) Stoichiometry and association constants of the inclusion complexes of ellipticine with modified β-cyclodextrin. Analyst, 121 (11). pp. 1561-1564.

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Abstract

Ellipticine is the most representative compound of the small family of pyrido4,3-bcarbazole alkaloids which exhibit antitumour activity. However, its use is plagued by problems associated with its insolubility in water and with its detection in clinical analysis. As the use of cyclodextrins (CDs) may alleviate these problems, the inclusion complexes obtained from ellipticine and γ-CD as well as a set of complexes with β-CD or modified β-CDs mere characterized by means of their stoichiometry and association constants. The stoichoimetry was 1:1 (ellipticine:CD) for complexes with β-CD and modified β-CDs and 1:2 for the ellipticine-γ-CD complex. Association constants were calculated using spectrofluorimetric data. As they depend on the pH of the medium, they were calculated for different pH values (1.0, 9.1 and 13.0). Modified β-CDs together with γ-CD gave the highest association constants. The association constants obtained for cationic and neutral ellipticine with the different β-CDs did not differ significantly. These results might lead to an improvement in the chromatographic analysis and clinical use of ellipticine.

Item Type: Article
Uncontrolled Keywords: cyclodextrin; ellipticine, article; complex formation; pH; solubility; spectrofluorometry; stoichiometry
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: SCIENTIFIC PRODUCTION > Biochemistry, Genetics and Molecular Biology
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:44
URI: http://eprints.umi.ac.ma/id/eprint/1623

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