Bendriss, E.K. and Bechtel, Y.C. and Paintaud, G. and Brientini, .P. and Mantion, G. and Miguet, J.P. and Bennani, A. and Bechtel, P.R. (1998) Acetylation polymorphism expression in patients before and after liver transplantation: Influence of host/graft genotypes. Pharmacogenetics, 8 (3). pp. 201-209.

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The consequences of liver transplantation on NAT2 activity were studied in 58 patients of Caucasian origin and compared with a group control of 119 unrelated healthy individuals of the same ethnic origin. Acetylation phenotypes were determined using caffeine as a probe drug before and repeatedly after liver transplantation. NAT2 genotypes were determined with three separate polymerase chain reactions to detect either the NAT(2*)4 wild-type allele or the NAT(2*)5A, NAT2(*)6A and NAT2(*)7A mutated alleles, associated with a decrease in NAT2 enzyme activity. In patients, the molar urinary elimination ratio AFMU/(AFMU + 1X + 1U) appeared more reliable than AFMU/1X for assessing the acetylation phenotype and fitted better with the various haplotypes. The variation of xanthine oxidase activity as measured by the 1U/1X urinary elimination ratio, appeared to be responsible for the poor phenotype prediction from the AFMU/1X ratio in post-transplanted patients. Regardless of the pathologic conditions or the treatment in progress, the genotype of the liver played an overwhelming role in the phenotypic expression of NAT2 compared with the genotype of other organs, where NAT2 was expressed in patients who presented a chimerism after liver transplantation.

Item Type: Article
Uncontrolled Keywords: azathioprine; caffeine; cyclosporin; prednisolone, acetylator phenotype; adult; article; chimera; drug acetylation; drug elimination; enzyme activity; follow up; graft versus host reaction; human; immunosuppressive treatment; liver metabolism; liver transplantation; major clinical study; polymerase chain reaction; postoperative complication; preoperative evaluation; priority journal; risk assessment, Acetylation; Adult; Aged; Alleles; Arylamine N-Acetyltransferase; Caffeine; Female; Genotype; Humans; Liver Transplantation; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Transplantation Chimera; Xanthine Oxidase
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: SCIENTIFIC PRODUCTION > Biochemistry, Genetics and Molecular Biology
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:44

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