Lamkadem, M. and Melhaoui, A. and Mimouni, J. and Fontange, R. and Buclon, M. (2000) Cytotoxic effect and electrophysiological activity of (S)-bgugaine, an alkylpyrrolidine alkaloid against MRC-5 fibroblasts. Phytomedicine, 7 (2). pp. 145-149.

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Abstract

(+)-S-bgugaine 1, is an alkaloid prepared by enantioselective synthesis. This alkaloid is an isomer of R-bgugaine 2, an alkaloid isolated from Arisarum vulgare, an Araceae toxic plant of Morocco. The cytotoxic effect and the electrophysiological activity of (+)-S-bgugaine 1 against MRC-5 fibroblasts of (+)-S-bgugaine 1, were studied. (+)-S-bgugaine 1 showed a cytotoxic potential at 40 μg/ml against these MRC-5 cells. The electrophysiological study on MRC-5 cells was carried out using the technique of patch-clamp and showed that the activity of compound I involved a reduction of outward potassic current at the concentration of 100 μM (28.1 μg/ml) and was accentuated by 200 μM (56.2 μg/ml). In this study we show that S-bgugaine 1, decreases the outward potassic current.

Item Type: Article
Uncontrolled Keywords: alkaloid; arisarum vulgare extract; bgugaine; plant extract; unclassified drug, article; concentration response; controlled study; cytotoxicity; drug isolation; drug structure; electrophysiology; fibroblast; human; human cell; Morocco; patch clamp; potassium current; priority journal, Araceae; Arisarum vulgare; Arisarum vulgare
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: SCIENTIFIC PRODUCTION > Biochemistry, Genetics and Molecular Biology
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:44
URI: http://eprints.umi.ac.ma/id/eprint/1608

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