Amine, A. and Atmani, Z. and El Hallaoui, A. and Giorgi, M. and Pierrot, M. and Réglier, M. (2002) Copper(II)/H2O2-mediated DNA cleavage: Involvement of a copper(III) species in H-atom abstraction of deoxyribose units. Bioorganic and Medicinal Chemistry Letters, 12 (1). pp. 57-60.

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A new bis-amido-copper(II) complex 2 has been prepared. In the presence of reducing agents (ascorbate or DTT) under air atmosphere or hydrogen peroxide, complex 2 exhibited interesting nuclease activities in the 1-10 μM concentration range. For explaining the activity observed with hydrogen peroxide, we propose the occurrence of a bis-amido-copper(III) intermediate and an oxidation mechanism involving a H-atom abstraction of deoxyribose moieties of DNA. © 2001 Elsevier Science Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: ascorbic acid; copper complex; deoxyribose; dithiothreitol; DNA; hydrogen; hydrogen peroxide; nuclease, article; atmosphere; chemical structure; concentration (parameters); DNA cleavage; enzyme activity; oxidation, Bacteriophages; Bleomycin; Copper; Deoxyribose; DNA; DNA Damage; Dose-Response Relationship, Drug; Drug Design; Hydrogen; Hydrogen Peroxide; Hydrolysis; Organometallic Compounds; Oxidation-Reduction; Structure-Activity Relationship
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: SCIENTIFIC PRODUCTION > Biochemistry, Genetics and Molecular Biology
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:44

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