Boukhabza, M. and El Hilaly, J. and Attiya, N. and El-Haidani, A. and Filali-Zegzouti, Y. and Mazouzi, D. and Amarouch, M.-Y. (2016) In silico evaluation of the potential antiarrhythmic effect of epigallocatechin-3-gallate on cardiac channelopathies. Computational and Mathematical Methods in Medicine, 2016.

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Ion channels are transmembrane proteins that allow the passage of ions according to the direction of their electrochemical gradients. Mutations in more than 30 genes encoding ion channels have been associated with an increasingly wide range of inherited cardiac arrhythmias. In this line, ion channels become one of the most important molecular targets for several classes of drugs, including antiarrhythmics. Nevertheless, antiarrhythmic drugs are usually accompanied by some serious side effects. Thus, developing new approaches could offer added values to prevent and treat the episodes of arrhythmia. In this sense, green tea catechins seem to be a promising alternative because of the significant effect of Epigallocatechin-3-Gallate (E3G) on the electrocardiographic wave forms of Guinea pig hearts. Thus, the aim of this study was to evaluate the benefits-risks balance of E3G consumption in the setting of ion channel mutations linked with aberrant cardiac excitability phenotypes. Two gain-of-function mutations, Na v1.5 -p.R222Q and Na v1.5 -p.I141V, which are linked with cardiac hyperexcitability phenotypes were studied. Computer simulations of action potentials (APs) show that 30 μM E3G reduces and suppresses AP abnormalities characteristics of these phenotypes. These results suggest that E3G may have a beneficial effect in the setting of cardiac sodium channelopathies displaying a hyperexcitability phenotype. © 2016 Maroua Boukhabza et al.

Item Type: Article
Uncontrolled Keywords: epigallocatechin gallate; ion channel; membrane protein; sodium channel Nav1.5; antiarrhythmic agent; catechin; epigallocatechin gallate; flavonoid; ion; tea, antiarrhythmic activity; Article; cardiac channelopathy; computer model; computer simulation; electrocardiography; evaluation study; gain of function mutation; heart conduction; heart muscle excitability; heart muscle potential; heart repolarization; phenotype; risk benefit analysis; action potential; analogs and derivatives; animal; biological model; cardiac muscle; Channelopathies; chemistry; cytology; drug effects; guinea pig; heart; heart atrium; heart ventricle; human; muscle cell; mutation; pathology; pathophysiology; Purkinje cell; tea, Action Potentials; Animals; Anti-Arrhythmia Agents; Catechin; Channelopathies; Computer Simulation; Flavonoids; Guinea Pigs; Heart; Heart Atria; Heart Ventricles; Humans; Ions; Models, Cardiovascular; Muscle Cells; Mutation; Myocardium; Phenotype; Purkinje Cells; Tea
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: SCIENTIFIC PRODUCTION > Biochemistry, Genetics and Molecular Biology
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:44

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