Bellocco, E. and Barreca, D. and Laganà, G. and Calderaro, A. and El Lekhlifi, Z. and Chebaibi, S. and Smeriglio, A. and Trombetta, D. (2016) Cyanidin-3-O-galactoside in ripe pistachio (Pistachia vera L. variety Bronte) hulls: Identification and evaluation of its antioxidant and cytoprotective activities. Journal of Functional Foods, 27. pp. 376-385.

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Abstract

Anthocyanidins, compounds with several health promoting properties, are able to influence a broad range of biological processes. In the present work we identified cyanidin-3-O-galactoside in ripe pistachio hulls, which represented the most abundant compound (>96), and we performed a deep analysis of its antioxidant and cytoprotective activities against tert-butyl hydroperoxide induced toxicity on human lymphocytes. Cyanidin-3-O-galactoside showed strong antioxidant activity in ORAC, DPPH•, ABTS•+, FRAP and O2•− assays, clearly superior to synthetic antioxidants BHT, BHA and Trolox, while no activity was detected with H2O2. Moreover, in the concentration range 0.1–10 µM, cyanidin-3-O-galactoside was found able to counteract cytotoxic effects of tert-butyl hydroperoxide decreasing or completely avoiding cell death, LDH release, caspase 3 activation and DNA damages. © 2016 Elsevier Ltd

Item Type: Article
Subjects: Agricultural and Biological Sciences
Divisions: SCIENTIFIC PRODUCTION > Agricultural and Biological Sciences
Depositing User: Administrateur Eprints Administrateur Eprints
Last Modified: 31 Jan 2020 15:44
URI: http://eprints.umi.ac.ma/id/eprint/1343

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